Twenty-two people have been killed and more than 50 injured in a suspected terror attack at Manchester Arena.
The blast happened at 22:35 BST on Monday following a pop concert by the US singer Ariana Grande.
Home Secretary Amber Rudd said it was "a barbaric attack, deliberately targeting some of the most vulnerable in our society".
At least 19 people were killed by an explosion at an Ariana Grande concert in the #ManchesterArena. pic.twitter.com/9WqgcFS5UW
— AJ+ (@ajplus) 23 May 2017
Relatives are using social media to hunt for missing loved ones, including children, caught up in the incident.
North West Ambulance Service said it had taken 59 casualties from the explosion to hospitals and treated a number of walking wounded, including for "shrapnel-like injuries".
Greater Manchester Police has established an emergency telephone number in response to the attack. It is: 0161 856 9400.
In light of the attack the Conservatives, Labour, SNP, Liberal Democrats and UKIP have all confirmed that Tuesday's campaigning in the general election has been suspended.
19 dead, 50 injured in #ManchesterArena explosion. Being treated as a terror incident. https://t.co/RaoedzKYpV pic.twitter.com/LJmydjJTnr
— BBC North West (@BBCNWT) 23 May 2017
The prime minister has announced she will chair a meeting of the government's emergency Cobra committee at around 09:00 BST.
Theresa May said: "We are working to establish the full details" of what happened in Manchester.
"All our thoughts are with the victims and the families of those who have been affected."
BBC home affairs correspondent Daniel Sandford said senior counter-terrorism officers were assembling in London and liaising with the Home Office.
Unconfirmed reports from two unnamed US officials suggested the attack was carried out by a suicide bomber.
Labour leader Jeremy Corbyn said he was "horrified" by the attack, adding: "Today the whole country will grieve for the people who have lost their lives."
Greater Manchester metro mayor Andy Burnham said: "My heart goes out to families who have lost loved ones, my admiration to our brave emergency services. A terrible night for our great city."
British Transport Police said the explosion was in the arena's foyer, which connects with Victoria train and tram station, a major hub on the northern edge of the city centre.
Shortly after the blast the station was closed and all trains cancelled.
Greater Manchester Police carried out a precautionary controlled explosion in the Cathedral Garden area of the city at about 01:32. The force later confirmed it was not a suspicious item.